Types Sex cord–gonadal stromal tumour

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video explanation of sex cord-stromal ovarian cancers


these tumours of following types, characterized abnormal production of otherwise apparently normal cells or tissues.



although each of cell , tissue types occurs in 1 sex (male or female), within tumour can occur in opposite sex. consequently, depending on specific histology produced, these tumours can cause virilization in women , feminization in men.


tumour types in order of prevalence

granulosa cell tumour. tumour produces granulosa cells, found in ovary. malignant in 20% of women diagnosed it. tends present in women in 50-55yo age group post menopausal vaginal bleeding. uncommonly, similar possibly distinct tumour, juvenile granulosa cell tumour, presents in pre-pubertal girls precocious puberty. in both groups, vaginal bleeding due oestrogen secreted tumour. in older women, treatment total abdominal hysterectomy , removal of both ovaries. in young girls, fertility sparing treatment mainstay non-metastatic disease.
sertoli cell tumour. tumour produces sertoli cells, found in testicle. tumour occurs in both men , women.
thecoma. tumour produces theca of follicle, tissue found in ovarian follicle. tumour exclusively benign , unilateral. typically secretes estrogen, , result women tumour present postmenopausal bleeding.
leydig cell tumour. tumour produces leydig cells, found in testicle , tend secrete androgens.
sertoli-leydig cell tumour. tumour produces both sertoli , leydig cells. although both cell types occur in testicle, tumour can occur in ovary.
gynandroblastoma. rare tumour producing both ovarian (granulosa and/or theca) , testicular (sertoli and/or leydig) cells or tissues. typically consists of adult-type granulosa cells , sertoli cells, has been reported juvenile-type granulosa cells. has been reported occur in ovary usually, in testis. due rarity, malignant potential of tumour unclear; there 1 case report of late metastasis.
sex cord tumour annular tubules, abbreviated sctat. these rare tumours may sporadic or associated peutz-jeghers syndrome.




^ chivukula, mamatha; hunt, jennifer; carter, gloria; kelley, joseph; patel, minita; kanbour-shakir, amal (2007). recurrent gynandroblastoma of ovary-a case report . international journal of gynecological pathology. 26 (1): 30–3. doi:10.1097/01.pgp.0000225387.48868.39. pmid 17197894. 
^ limaïem, f; lahmar, a; ben fadhel, c; bouraoui, s; m zabi-regaya, s (2008). gynandroblastoma. report of unusual ovarian tumour , literature review . pathologica. 100 (1): 13–7. pmid 18686520. 
^ broshears, john r.; roth, lawrence m. (1997). gynandroblastoma elements resembling juvenile granulosa cell tumor . international journal of gynecological pathology. 16 (4): 387–91. doi:10.1097/00004347-199710000-00016. pmid 9421080. 
^ antunes, l; ounnoughene-piet, m; hennequin, v; maury, f; lemelle, j-l; labouyrie, e; plenat, f (2002). gynandroblastoma of testis in infant: morphological, immunohistochemical , in-situ hybridization report . histopathology. 40 (4): 395–7. doi:10.1046/j.1365-2559.2002.t01-2-01299.x. pmid 11943029. 






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